Inhalation of the nerve gas sarin impairs ventilatory responses to hypercapnia and hypoxia in rats☆
نویسندگان
چکیده
منابع مشابه
Ventilatory and metabolic responses to ambient hypoxia or hypercapnia in rats exposed to CO hypoxia.
We have investigated at ambient temperatures (Tam) of 25 and 5 degrees C the effects of ambient hypoxia (Hxam; fractional inspired O2 = 0.14) and hypercapnia (fractional inspired CO2 = 0.04) on ventilation (V), O2 uptake (VO2), and colonic temperature (Tc) in 12 conscious rats before and after carotid body denervation (CBD). The rats were concomitantly exposed to CO hypoxia (HxCO; fractional in...
متن کاملFructose feeding and intermittent hypoxia affect ventilatory responsiveness to hypoxia and hypercapnia in rats.
We hypothesized that, in male rats, 10% fructose in drinking water would depress ventilatory responsiveness to acute hypoxia (10% O2 in N2) and hypercapnia (5% CO2 in O2) that would be depressed further by exposure to intermittent hypoxia. Minute ventilation (Ve) in air and in response to acute hypoxia and hypercapnia was evaluated in 10 rats before fructose feeding (FF), during 6 wk of FF, and...
متن کاملVentilatory responses to hypercapnia and hypoxia in relatives of patients with the obesity hypoventilation syndrome.
BACKGROUND It is unclear why some morbidly obese individuals have waking alveolar hypoventilation while others with similar obesity do not. Some evidence suggests that patients with the obesity hypoventilation syndrome (OHS) may have a measurable premorbid impairment of ventilatory chemoresponsiveness. Such an impairment of ventilatory chemoresponsiveness in OHS, however, may be an acquired and...
متن کاملBehavioral, Ventilatory and Thermoregulatory Responses to Hypercapnia and Hypoxia in the Wistar Audiogenic Rat (WAR) Strain
INTRODUCTION We investigated the behavioral, respiratory, and thermoregulatory responses elicited by acute exposure to both hypercapnic and hypoxic environments in Wistar audiogenic rats (WARs). The WAR strain represents a genetic animal model of epilepsy. METHODS Behavioral analyses were performed using neuroethological methods, and flowcharts were constructed to illustrate behavioral findin...
متن کاملHemodynamic and ventilatory response to different levels of hypoxia and hypercapnia in carotid body-denervated rats
OBJECTIVE Chemoreceptors play an important role in the autonomic modulation of circulatory and ventilatory responses to changes in arterial O(2) and/or CO(2). However, studies evaluating hemodynamic responses to hypoxia and hypercapnia in rats have shown inconsistent results. Our aim was to evaluate hemodynamic and respiratory responses to different levels of hypoxia and hypercapnia in consciou...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2008
ISSN: 0041-008X
DOI: 10.1016/j.taap.2008.07.016